Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.51 |
| ▸ | HTR1A | P08908 | 6/20 | 0.51 |
| ▸ | DRD2 | P14416 | 6/20 | 0.51 |
| ▸ | HTR1D | P28221 | 6/20 | 0.51 |
| ▸ | HTR1B | P28222 | 6/20 | 0.51 |
| ▸ | DRD3 | P35462 | 6/20 | 0.51 |
| ▸ | HTR2C | P28335 | 5/20 | 0.51 |
| ▸ | HTR7 | P34969 | 5/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 5/20 | 0.51 |
| ▸ | HTR2A | P28223 | 5/20 | 0.51 |
| ▸ | HTR2B | P41595 | 5/20 | 0.51 |
| ▸ | HTR1E | P28566 | 3/20 | 0.51 |
| ▸ | HTR1F | P30939 | 3/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413695 | 0.90 | HTR6 (0.53) | HTR6ADRA1BHTR1ADRD2HTR1D | |
| SCHEMBL7197257 | 0.81 | HTR6 (0.77) | HTR6ADRA1BHTR1ADRD2HTR1D | |
| SCHEMBL7035600 | 0.80 | OPRK1 (0.49) | ADRA1BHTR1ADRD2HTR1DHTR2C | |
| SCHEMBL7200247 | 0.69 | HTR6 (0.77) | HTR6ADRA1BHTR1ADRD2HTR1D | |
| SCHEMBL2226181 | 0.69 | NPSR1 (0.60) | CMA1 | |
| SCHEMBL13698528 | 0.68 | DRD2 (0.59) | ADRA1BHTR1ADRD2DRD4OPRM1 | |
| SCHEMBL1136525 | 0.68 | HTR6 (1.00) | HTR6ADRA1BHTR1ADRD2HTR1D | |
| SCHEMBL29496144 | 0.68 | HTR6 (1.00) | HTR6ADRA1BHTR1ADRD2HTR1D | |
| Hydrochloric Acid SCHEMBL6712744 | 0.68 | NPSR1 (0.59) | CMA1 | |
| SCHEMBL7200046 | 0.67 | HTR6 (0.76) | HTR6ADRA1BHTR1ADRD2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946539-A1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1999-10-06 | — | — | EP | claimed |
| WO-1998027081-A1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1998-06-25 | — | — | WO | claimed |