Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.31 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL338812 | 0.79 | ADRB2 (0.45) | THRBDNM1CYP3A4ALDH1A1ADRB2 | |
| SCHEMBL3260445 | 0.77 | DNM1 (0.52) | THRBDNM1ALDH1A1LPAR1LPAR3 | |
| SCHEMBL11101061 | 0.74 | DNM1 (0.56) | THRBDNM1LPAR1LPAR3CA1 | |
| SCHEMBL7778179 | 0.74 | DNM1 (0.56) | THRBDNM1LPAR1LPAR3CA1 | |
| SCHEMBL6180238 | 0.74 | DNM1 (0.56) | THRBDNM1LPAR1LPAR3CA1 | |
| SCHEMBL17102803 | 0.74 | ADRB2 (0.41) | THRBDNM1CYP3A4ALDH1A1ADRB2 | |
| SCHEMBL4594523 | 0.74 | DNM1 (0.56) | THRBDNM1LPAR1LPAR3CA1 | |
| SCHEMBL18240005 | 0.74 | DNM1 (0.56) | THRBDNM1LPAR1LPAR3CA1 | |
| SCHEMBL10937950 | 0.74 | LMNA (0.55) | THRB | |
| SCHEMBL27203931 | 0.73 | EPHX2 (0.38) | DNM1CYP3A4ALDH1A1LPAR1LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594006-A | SUCH AS COLLEGENASE, STROMELYSIN; ANTICANCER AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-14 | — | — | US | disclosed |
| EP-0641323-A1 | CARBOSTYRIL DERIVATIVES AS MATRIX METALLOPROTEINASES INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-03-08 | — | — | EP | disclosed |
| WO-1994021612-A1 | CARBOSTYRIL DERIVATIVES AS MATRIX METALLOPROTEINASES INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-29 | — | — | WO | disclosed |