Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | BAD | Q92934 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7810685 | 0.88 | TBXAS1 (0.46) | PTPN1TBXAS1CES2CES1BCL2L1 | |
| SCHEMBL5089367 | 0.86 | TBXAS1 (0.48) | PTPN1TBXAS1NPC1RAB9AHTR1A | |
| SCHEMBL9377885 | 0.83 | PTPN1 (0.48) | PTPN1TBXAS1CES2CES1BCL2L1 | |
| SCHEMBL8675717 | 0.79 | TBXAS1 (0.41) | PTPN1TBXAS1CES2CES1BCL2L1 | |
| SCHEMBL11994159 | 0.79 | POLB (0.49) | PTPN1TBXAS1CES2CES1BCL2L1 | |
| SCHEMBL5636607 | 0.79 | BCL2L1 (0.42) | PTPN1TBXAS1CES2CES1BCL2L1 | |
| SCHEMBL9377011 | 0.79 | BCL2L1 (0.59) | CES2CES1BCL2L1 | |
| SCHEMBL4535241 | 0.78 | SIGMAR1 (0.47) | PTPN1TBXAS1 | |
| SCHEMBL23880653 | 0.78 | TBXAS1 (0.47) | PTPN1TBXAS1CES2CES1BCL2L1 | |
| SCHEMBL11994148 | 0.76 | HTR7 (0.50) | TBXAS1PTGS2POLBGAAHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250537-A | Treating psychoses | SCIOS NOVA INC. (US) | 1993-10-05 | — | — | US | disclosed |
| US-4514414-A | NEUROLEPTIC AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1985-04-30 | — | — | US | disclosed |
| EP-0066456-B1 | N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND THEIR ESTERS | SMITHKLINE BECKMAN CORPORATION (US) | 1985-04-24 | — | — | EP | disclosed |
| EP-0066456-A1 | N-substituted azaheterocyclic carboxylic acids and their esters | SMITHKLINE BECKMAN CORPORATION (US) | 1982-12-08 | — | — | EP | disclosed |