Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 3/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406955 | 0.82 | CHRNB2 (0.39) | CHRNB2CHRNA4 | |
| SCHEMBL7414013 | 0.78 | CHRNB2 (0.40) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL7412190 | 0.77 | BTK (0.30) | — | |
| SCHEMBL7414707 | 0.77 | CHRNB2 (0.37) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL8508196 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL7409631 | 0.76 | CHRNB2 (0.36) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL6583401 | 0.73 | CHRNA3 (0.62) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL4960797 | 0.73 | CHRNA3 (0.54) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| Hydrochloric Acid SCHEMBL6584592 | 0.72 | CHRNA3 (0.61) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL8506370 | 0.71 | MEN1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |