Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406955 | 0.81 | CHRNB2 (0.39) | CHRNB2CHRNA4 | |
| SCHEMBL7414707 | 0.79 | CHRNB2 (0.37) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL7413813 | 0.78 | CHRNB4 (0.33) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL7409631 | 0.78 | CHRNB2 (0.36) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4960797 | 0.75 | CHRNA3 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2 | |
| SCHEMBL3719165 | 0.74 | ACACB (0.47) | CHRNB2CHRNA4 | |
| SCHEMBL8550718 | 0.74 | MEN1 (0.33) | CHRNB2CHRNA4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8551060 | 0.74 | MEN1 (0.33) | CHRNB2CHRNA4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7410743 | 0.74 | CHRNB2 (0.64) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL7408955 | 0.74 | CHRNB2 (0.64) | CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |