Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 15/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 14/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 2/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413005 | 0.97 | ITGB3 (0.50) | ITGB3ITGA2BCYP3A4CYP2C19L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL7410411 | 0.93 | L3MBTL1 (0.49) | ITGB3ITGA2BCYP2C19L3MBTL1POLB | |
| SCHEMBL7418586 | 0.90 | CYP3A4 (0.41) | ITGB3ITGA2BCYP3A4CYP2C19L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL7415440 | 0.89 | ITGB3 (0.49) | ITGB3ITGA2BPOLBPPARGITGAV | |
| Trifluoroacetic Acid SCHEMBL7418348 | 0.88 | TYMS (0.45) | ITGB3ITGA2BL3MBTL1POLBPPARG | |
| SCHEMBL7412781 | 0.88 | L3MBTL1 (0.53) | ITGB3ITGA2BCYP2C19L3MBTL1POLB | |
| Trifluoroacetic Acid SCHEMBL7408388 | 0.88 | ITGB3 (0.47) | ITGB3ITGA2BITGB1PPARGITGA4 | |
| Trifluoroacetic Acid SCHEMBL7699204 | 0.86 | ITGB3 (0.51) | ITGB3ITGA2BL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL7412868 | 0.86 | ITGB3 (0.47) | ITGB3ITGA2BITGB1PPARGITGA4 | |
| Trifluoroacetic Acid SCHEMBL7415198 | 0.86 | ITGB3 (0.63) | ITGB3ITGA2BITGB1PPARGITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | disclosed |
| EP-1161280-A1 | USE OF AN INTEGRIN ANTAGONIST AND A CHEMOTHERAPEUTIC AGENT IN THE TREATMENT OF NEOPLASIA | G.D. Searle & Co. (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000051686-A1 | USE OF INTEGRIN ANTAGONIST AND A CHEMOTHERAPEUTIC AGENT IN THE TREATMENT OF NEOPLASIA | G.D. SEARLE & CO. (US) | 2000-09-08 | — | — | WO | disclosed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | disclosed |