Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 4/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739438 | 0.86 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL3477086 | 0.82 | ALDH1A1 (0.37) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL19141297 | 0.70 | MAPT (0.69) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL19140438 | 0.69 | MAPT (0.68) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL10241785 | 0.68 | MAPT (0.75) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL19140509 | 0.67 | ALDH1A1 (0.65) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL14926951 | 0.67 | ALDH1A1 (0.40) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL739356 | 0.67 | ALDH1A1 (0.37) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL17973370 | 0.65 | MAPT (0.66) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL6999008 | 0.65 | ALDH1A1 (0.69) | ALDH1A1KDM4EMAPTGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430029-A1 | THIENO [2, 3-B]PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | Katholieke Universiteit Leuven (BE) | 2012-03-21 | — | — | EP | disclosed |