Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.33 |
| ▸ | FASN | P49327 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | GYS1 | P13807 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210609 | 0.73 | SMN1; SMN2 (0.49) | MAPTL3MBTL1 | |
| SCHEMBL6632710 | 0.67 | NPC1 (0.34) | MAPTABCC8KCNJ11FASNL3MBTL1 | |
| SCHEMBL12121211 | 0.63 | DYRK1A (0.46) | L3MBTL1 | |
| SCHEMBL8812221 | 0.63 | FASN (0.34) | MAPTABCC8KCNJ11FASNGYS1 | |
| SCHEMBL12124200 | 0.62 | NR2F2 (0.33) | L3MBTL1NR2F2 | |
| SCHEMBL1829755 | 0.60 | L3MBTL1 (0.32) | MAPTL3MBTL1GYS1MEN1CNR1 | |
| SCHEMBL16797223 | 0.60 | L3MBTL1 (0.47) | L3MBTL1KMT2A | |
| SCHEMBL21462360 | 0.60 | — | — | |
| SCHEMBL694899 | 0.60 | KIF11 (0.43) | — | |
| SCHEMBL8460364 | 0.60 | ABCC8 (0.38) | MAPTABCC8KCNJ11FASNGYS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002012193-A1 | TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID ALKOXYGUANIDINES AS INTEGRIN ANTAGONISTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2002-02-14 | — | — | WO | disclosed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | disclosed |