Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.46 |
| ▸ | MB | P02144 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25300707 | 0.75 | AHR (0.49) | CYP11B1CYP11B2PDE3BPDE3ACRBN | |
| SCHEMBL429197 | 0.71 | PDE3B (0.58) | CYP11B1CYP11B2MBPDE3BPDE3A | |
| SCHEMBL25242815 | 0.71 | MKNK2 (0.45) | — | |
| SCHEMBL24680963 | 0.71 | CYP11B1 (0.46) | CYP11B1CYP11B2PDE3BPDE3A | |
| SCHEMBL16318310 | 0.69 | CMA1 (0.59) | CYP11B1CYP11B2MBPDE3BPDE3A | |
| SCHEMBL6684530 | 0.69 | CYP11B1 (0.53) | CYP11B1CYP11B2MBPDE3BPDE3A | |
| SCHEMBL31173261 | 0.69 | CMA1 (0.59) | CYP11B1CYP11B2MBPDE3BPDE3A | |
| SCHEMBL23302034 | 0.69 | MB (0.49) | CYP11B1CYP11B2MBPDE3BPDE3A | |
| SCHEMBL7419264 | 0.69 | BIRC2 (0.37) | CYP11B1CYP11B2MBPDE3BPDE3A | |
| SCHEMBL15951381 | 0.69 | MB (0.66) | CYP11B1CYP11B2MBPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0333727-A1 | HETEROCYCLIC SUBSTITUTED BICYCLOUREAS HAVING CARDIOTONIC ACTIVITY | RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) (US) | 1989-09-27 | — | — | EP | disclosed |
| US-4859672-A | Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone | RORER PHARMACEUTICAL CORPORATION (US) | 1989-08-22 | — | — | US | disclosed |
| WO-1988003025-A1 | HETEROCYCLIC SUBSTITUTED BICYCLOUREAS HAVING CARDIOTONIC ACTIVITY | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1988-05-05 | — | — | WO | disclosed |