Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.58 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.51 |
| ▸ | CMA1 | P23946 | 1/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16318310 | 0.87 | CMA1 (0.59) | PDE3BPDE3ABRD4CYP11B1CYP11B2 | |
| SCHEMBL31173261 | 0.87 | CMA1 (0.59) | PDE3BPDE3ABRD4CYP11B1CYP11B2 | |
| SCHEMBL4899191 | 0.82 | PARP10 (0.56) | PDE3BPDE3ABRD4CYP11B1CYP11B2 | |
| SCHEMBL15373652 | 0.80 | PNMT (0.45) | BRD4CMA1AHRPARP10TDP2 | |
| SCHEMBL25367020 | 0.78 | BRD4 (0.44) | PDE3BPDE3ABRD4CMA1AHR | |
| SCHEMBL30528610 | 0.78 | BRD4 (0.44) | PDE3BPDE3ABRD4CMA1AHR | |
| SCHEMBL29546522 | 0.78 | PDE3B (0.58) | PDE3BPDE3ACYP11B1CYP11B2CA12 | |
| SCHEMBL8551799 | 0.78 | PDE3B (0.58) | PDE3BPDE3ACYP11B1CYP11B2AHR | |
| SCHEMBL3640443 | 0.78 | PDE3B (0.58) | PDE3BPDE3ABRD4CYP11B1CYP11B2 | |
| SCHEMBL13496007 | 0.78 | PDE3B (0.58) | PDE3BPDE3ABRD4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12018016-B2 | Aryl sulfonyl (hydroxy) piperidines as CCR6 inhibitors | AMGEN INC. (US) | 2024-06-25 | — | — | US | disclosed |
| CN-117813086-A | Arylsulfonyl (hydroxy) piperidines as CCR6 inhibitors | 坎莫森特里克斯公司 | 2024-04-02 | — | — | CN | disclosed |
| US-20230133406-A1 | Aryl Sulfonyl (Hydroxy) Piperidines as CCR6 Inhibitors | CHEMOCENTRYX, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20150374695-A1 | 6-PIPERAZINYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-12-31 | — | — | US | disclosed |
| US-20150374695-A1 | 6-PIPERAZINYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-12-31 | — | — | US | disclosed |
| US-20150374695-A1 | 6-PIPERAZINYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-12-31 | — | — | US | disclosed |
| US-9205087-B1 | 6-Piperazinyl-3,4-dihydroquinazolin-2(1H)-ones | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-12-08 | — | — | US | disclosed |
| US-9205087-B1 | 6-Piperazinyl-3,4-dihydroquinazolin-2(1H)-ones | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-12-08 | — | — | US | disclosed |
| US-9205087-B1 | 6-Piperazinyl-3,4-dihydroquinazolin-2(1H)-ones | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-12-08 | — | — | US | disclosed |
| US-9199969-B1 | 6-piperazinyl-3,4-dihydroquinazolin-2(1H)-ones | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-12-01 | — | — | US | disclosed |
| US-9199969-B1 | 6-piperazinyl-3,4-dihydroquinazolin-2(1H)-ones | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-12-01 | — | — | US | disclosed |
| US-9199969-B1 | 6-piperazinyl-3,4-dihydroquinazolin-2(1H)-ones | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-12-01 | — | — | US | disclosed |
| US-9145388-B2 | 6-piperazinyl-3,4-dihydroquinazolin-2(1H)-ones | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-09-29 | — | — | US | disclosed |
| US-9145388-B2 | 6-piperazinyl-3,4-dihydroquinazolin-2(1H)-ones | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-09-29 | — | — | US | disclosed |
| US-9145388-B2 | 6-piperazinyl-3,4-dihydroquinazolin-2(1H)-ones | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-09-29 | — | — | US | disclosed |
| US-20150232448-A1 | 6-PIPERAZINYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES | KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY (SA) | 2015-08-20 | — | — | US | disclosed |
| US-20150232448-A1 | 6-PIPERAZINYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES | KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY (SA) | 2015-08-20 | — | — | US | disclosed |
| US-20150232448-A1 | 6-PIPERAZINYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES | KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY (SA) | 2015-08-20 | — | — | US | disclosed |
| US-20120022058-A1 | 4,5-DIHYDRO-1H-PYRAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL USES | PFIZER INC. | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133406-A1 | Aryl Sulfonyl (Hydroxy) Piperidines as CCR6 Inhibitors | CCR6, CCR1, CCR4 | PDE3B 1875/4885PDE3A 1816/4885BRD4 403/4885 |
| US-12018016-B2 | Aryl sulfonyl (hydroxy) piperidines as CCR6 inhibitors | CCR6, CCR1, CCR4 | PDE3B 1875/4885PDE3A 1816/4885BRD4 403/4885 |
| US-20120022058-A1 | 4,5-DIHYDRO-1H-PYRAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL USES | NR3C2, REN, AGTR1 | PDE3B 98/4885PDE3A 132/4885BRD4 422/4885 |
| US-20150374695-A1 | 6-PIPERAZINYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES | HTR2C, HTR2A, HTR1B | PDE3B 1843/4885PDE3A 1827/4885BRD4 92/4885 |
| US-20150232448-A1 | 6-PIPERAZINYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES | HTR2C, HTR2A, HTR1B | PDE3B 1843/4885PDE3A 1827/4885BRD4 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.