Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.77 |
| ▸ | MMP13 | P45452 | 16/20 | 0.65 |
| ▸ | MMP8 | P22894 | 4/20 | 0.65 |
| ▸ | MMP2 | P08253 | 4/20 | 0.65 |
| ▸ | MMP7 | P09237 | 3/20 | 0.65 |
| ▸ | MMP9 | P14780 | 14/20 | 0.63 |
| ▸ | MMP1 | P03956 | 13/20 | 0.63 |
| ▸ | MMP14 | P50281 | 2/20 | 0.51 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7356912 | 0.83 | ADAM17 (0.65) | ADAM17MMP13MMP8MMP2MMP7 | |
| SCHEMBL6508472 | 0.83 | ADAM17 (0.76) | ADAM17MMP13MMP8MMP2MMP7 | |
| SCHEMBL6330964 | 0.82 | ADAM17 (0.52) | ADAM17MMP13MMP8MMP2MMP7 | |
| SCHEMBL7354960 | 0.81 | ADAM17 (0.80) | ADAM17MMP13MMP8MMP2MMP7 | |
| SCHEMBL6499544 | 0.81 | ADAM17 (0.77) | ADAM17MMP13MMP8MMP2MMP7 | |
| SCHEMBL6323461 | 0.80 | CA12 (0.51) | ADAM17MMP13MMP8MMP2MMP9 | |
| SCHEMBL6674336 | 0.80 | ADAM17 (0.67) | ADAM17MMP13MMP8MMP2MMP7 | |
| SCHEMBL6325698 | 0.79 | KEAP1 (0.51) | ADAM17MMP13MMP8MMP2MMP7 | |
| SCHEMBL6499433 | 0.79 | ADAM17 (0.78) | ADAM17MMP13MMP8MMP2MMP7 | |
| SCHEMBL6325897 | 0.78 | MMP2 (0.60) | ADAM17MMP13MMP2MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149074-A1 | ACETYLENIC SULFONAMIDE THIOL TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000044716-A1 | ACETYLENIC SULFONAMIDE THIOL TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |