SCHEMBL7415045

SCHEMBL7415045

N#Cc1cncc(C(=O)O)n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.41
HCAR2 Q8TDS4 2/20 0.41
NAPRT Q6XQN6 1/20 0.41
ALOX15 P16050 3/20 0.36
ALDH1A1 P00352 1/20 0.36
HPGD P15428 1/20 0.36
HSD17B10 Q99714 1/20 0.36
TSHR P16473 3/20 0.35
ACMSD Q8TDX5 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
CYP11B1 P15538 1/20 0.35
CYP11B2 P19099 1/20 0.35
HIF1A Q16665 1/20 0.34
POLB P06746 1/20 0.34
SLC22A12 Q96S37 2/20 0.34
CTSS P25774 2/20 0.33
EIF4EBP1 Q13541 1/20 0.33
P4HA1 P13674 1/20 0.31
MIF P14174 1/20 0.31
P4HTM Q9NXG6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL69399 0.78 KDM4E (0.55) KDM4EHCAR2NAPRTALOX15ALDH1A1
SCHEMBL3293682 0.75 CYP11B1 (0.44) CYP11B1CYP11B2CTSS
SCHEMBL1244495 0.72 KDM4E (0.61) KDM4ENAPRTALOX15TSHRACMSD
SCHEMBL162262 0.70 HCAR2 (0.46) KDM4EHCAR2NAPRTALOX15ALDH1A1
SCHEMBL31118151 0.70 HCAR2 (0.46) KDM4EHCAR2NAPRTALOX15ALDH1A1
SCHEMBL162261 0.70 HCAR2 (0.46) KDM4EHCAR2NAPRTALOX15ALDH1A1
SCHEMBL11023993 0.69 KDM4E (0.42) KDM4EHCAR2NAPRTALOX15ALDH1A1
SCHEMBL14151161 0.69 ALOX15 (0.41) KDM4EALOX15TSHRACMSDTDP1
SCHEMBL20929039 0.68 KDM4E (0.45) KDM4EHCAR2NAPRTALOX15ALDH1A1
SCHEMBL14764682 0.68 HCAR2 (0.45) KDM4EHCAR2NAPRTALOX15ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022092180-A1 NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUND HAVING OXIME GROUP, AGRICULTURAL/HORTICULTURAL HERBICIDE CONTAINING SAID COMPOUND, AND USE THEREOF 日本農薬株式会社 2022-05-05 WO disclosed
CN-108697699-A Heterocyclic PDK1 inhibitors for the treatment of cancer 苏尼西斯制药有限公司 2018-10-23 CN disclosed
US-5849693-A Cyclic compounds linked by a heterocyclic ring useful as inhibitors of platelet glycoprotein IIb/IIIa THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1998-12-15 US disclosed
US-5773411-A CARDIOVASCULAR DISORDERS AND BRAIN DISORDERS AND COAGULANTS THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1998-06-30 US disclosed
EP-0672059-A1 CYCLIC COMPOUNDS LINKED BY A HETEROCYCLIC RING USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1995-09-20 EP disclosed
WO-1994011398-A1 CYCLIC COMPOUNDS LINKED BY A HETEROCYCLIC RING USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-05-26 WO disclosed