Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 6/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12466814 | 0.88 | MLYCD (0.58) | MLYCDALDH1A1EPHX2POLBTDP1 | |
| SCHEMBL5125127 | 0.83 | GAA (0.61) | ALDH1A1EPHX2POLBTDP1MAPT | |
| SCHEMBL24575916 | 0.80 | EPHX2 (0.83) | ALDH1A1EPHX2POLBTDP1MAPT | |
| SCHEMBL18415483 | 0.80 | POLB (0.77) | ALDH1A1EPHX2POLBTDP1MAPT | |
| SCHEMBL14694017 | 0.80 | ALDH1A1 (0.66) | ALDH1A1EPHX2POLBTDP1MAPT | |
| SCHEMBL1455280 | 0.78 | ALDH1A1 (0.64) | ALDH1A1EPHX2POLBTDP1MAPT | |
| SCHEMBL1694937 | 0.78 | ALDH1A1 (0.64) | ALDH1A1EPHX2POLBTDP1MAPT | |
| SCHEMBL29410065 | 0.78 | ALDH1A1 (0.74) | ALDH1A1EPHX2POLBTDP1MAPT | |
| SCHEMBL19726946 | 0.78 | ALDH1A1 (0.59) | ALDH1A1EPHX2POLBTDP1MAPT | |
| SCHEMBL20863087 | 0.78 | GAA (0.56) | ALDH1A1EPHX2POLBTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230225-A2 | PHARMACEUTICALLY ACTIVE 4-SUBSTITUTED PYRIMIDINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001032632-A2 | PHARMACEUTICALLY ACTIVE 4-SUBSTITUTED PYRIMIDINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-05-10 | — | — | WO | disclosed |