Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 7/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415087 | 0.88 | MLYCD (0.64) | MLYCDALDH1A1EPHX2POLBTDP1 | |
| SCHEMBL5125127 | 0.81 | GAA (0.61) | ALDH1A1EPHX2POLBTDP1HPGD | |
| SCHEMBL18415483 | 0.78 | POLB (0.77) | ALDH1A1EPHX2POLBTDP1HPGD | |
| SCHEMBL14694017 | 0.78 | ALDH1A1 (0.66) | ALDH1A1EPHX2POLBTDP1HPGD | |
| SCHEMBL24575916 | 0.78 | EPHX2 (0.83) | ALDH1A1EPHX2POLBTDP1HPGD | |
| SCHEMBL1455280 | 0.77 | ALDH1A1 (0.64) | ALDH1A1EPHX2POLBTDP1HPGD | |
| SCHEMBL1694937 | 0.77 | ALDH1A1 (0.64) | ALDH1A1EPHX2POLBTDP1HPGD | |
| SCHEMBL29410065 | 0.77 | ALDH1A1 (0.74) | ALDH1A1EPHX2POLBTDP1HPGD | |
| SCHEMBL28733080 | 0.77 | ALDH1A1 (0.55) | ALDH1A1EPHX2POLBTDP1HPGD | |
| SCHEMBL19726946 | 0.76 | ALDH1A1 (0.59) | ALDH1A1EPHX2POLBTDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668160-B1 | TRPM8 RECEPTOR ANTAGONISTS | DOMPÉ FARMACEUTICI S P A (IT) | 2015-08-12 | — | — | EP | disclosed |
| US-8906946-B2 | TRPM8 receptor antagonists | DOMPE' S.P.A. (IT) | 2014-12-09 | — | — | US | disclosed |
| US-20140031398-A1 | TRPM8 RECEPTOR ANTAGONISTS | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2014-01-30 | — | — | US | disclosed |
| EP-2668160-A1 | TRPM8 RECEPTOR ANTAGONISTS | Dompe' S.p.A. (IT) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101244-A1 | TRPM8 RECEPTOR ANTAGONISTS | DOMPE' S.P.A. (IT) | 2012-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031398-A1 | TRPM8 RECEPTOR ANTAGONISTS | TRPM8, TRPM6, TRPM7 | MLYCD 4504/4885ALDH1A1 4725/4885EPHX2 1740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.