Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8508960 | 0.95 | SLC6A3 (0.34) | — | |
| SCHEMBL7409594 | 0.90 | SLC6A3 (0.32) | CHRNB2CHRNA4 | |
| SCHEMBL7411066 | 0.88 | ALDH1A1 (0.33) | KMT2A | |
| SCHEMBL8507356 | 0.88 | ALDH1A1 (0.33) | KMT2A | |
| SCHEMBL8553829 | 0.87 | — | — | |
| SCHEMBL8508197 | 0.85 | — | — | |
| SCHEMBL7414522 | 0.85 | — | — | |
| SCHEMBL7409484 | 0.85 | GPR119 (0.34) | — | |
| SCHEMBL7410586 | 0.85 | SLC6A3 (0.37) | — | |
| SCHEMBL7408025 | 0.85 | JAK2 (0.33) | LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |