Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6465214 | 0.81 | CCR6 (0.52) | ALOX5ADRA1ASLC6A3HDAC3HDAC4 | |
| SCHEMBL7405546 | 0.81 | NPC1 (0.48) | SMN1; SMN2RENNPC1RAB9ATDP1 | |
| Hydrochloric Acid SCHEMBL11685888 | 0.79 | NPC1 (0.47) | SMN1; SMN2RENNPC1RAB9ATDP1 | |
| SCHEMBL9536343 | 0.79 | L3MBTL1 (0.45) | ALOX5ADRA1ASLC6A3HDAC3HDAC1 | |
| SCHEMBL4773352 | 0.78 | HDAC2 (0.60) | ALOX5ADRA1ASLC6A3HDAC3HDAC4 | |
| SCHEMBL23743682 | 0.78 | LPAR1 (0.43) | ALOX5ADRA1ASLC6A3HDAC3HDAC4 | |
| SCHEMBL4669762 | 0.77 | ALOX5 (0.50) | ALOX5ADRA1ASLC6A3HDAC3HDAC4 | |
| SCHEMBL6981878 | 0.77 | KCNH2 (0.52) | ALOX5ADRA1ASLC6A3HDAC3HDAC4 | |
| SCHEMBL5540861 | 0.76 | SIGMAR1 (0.47) | ALOX5ADRA1ASLC6A3RENCHRM2 | |
| SCHEMBL23121020 | 0.76 | ALOX5 (0.49) | ALOX5ADRA1ASLC6A3HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161422-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055144-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |