Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428336 | 0.83 | TRPM8 (0.47) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7790927 | 0.78 | RAB9A (0.59) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7185571 | 0.76 | RAB9A (0.56) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9506390 | 0.75 | RAB9A (0.62) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7093267 | 0.75 | ALDH1A1 (0.56) | NPC1KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7310816 | 0.75 | MEN1 (0.63) | NPC1KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL11190772 | 0.74 | RAB9A (0.72) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9775596 | 0.73 | ALDH1A1 (0.54) | NPC1KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2950703 | 0.73 | ALDH1A1 (0.54) | NPC1KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL13243841 | 0.73 | ALDH1A1 (0.54) | NPC1KMT2AMEN1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265903-A1 | THIEPINO[3,2-B]DIHYDROPYRIDINES AND RELATED COMPOSITIONS AND METHODS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6420383-B1 | CALCIUM CHANNEL BLOCKERS, HYPERSENSITIVITY, ALLERGY, ASTHMA, BRONCHOSPASM, DYSMENORRHEA, ESOPHAGEAL SPASM, GLAUCOMA, PREMATURE LABOR, URINARY TRACT DISORDERS, GASTROINTESTINAL MOTILITY DISORDERS AND CARDIOVASCULAR DISORDERS. | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-07-16 | — | — | US | disclosed |
| WO-2001070748-A1 | THIEPINO [3,2-b] DIHYDROPYRIDINES AND RELATED COMPOSITIONS AND METHODS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-09-27 | — | — | WO | disclosed |