Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | LAP3 | P28838 | 3/20 | 0.47 |
| ▸ | ANPEP | P15144 | 4/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.42 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762691 | 1.00 | LTA4H (0.61) | LTA4HHDAC1HDAC6LAP3ANPEP | |
| SCHEMBL741542 | 1.00 | LTA4H (0.61) | LTA4HHDAC1HDAC6LAP3ANPEP | |
| SCHEMBL7960649 | 0.86 | LTA4H (0.67) | LTA4HLAP3ESR1ESR2KMT2A | |
| SCHEMBL7415465 | 0.86 | LTA4H (0.67) | LTA4HLAP3ESR1ESR2KMT2A | |
| SCHEMBL7961571 | 0.84 | LTA4H (0.69) | LTA4HLAP3ACACBPOLB | |
| SCHEMBL6339522 | 0.84 | LTA4H (0.77) | LTA4HLAP3ANPEPRNPEPDNPEP | |
| SCHEMBL2106650 | 0.84 | LTA4H (0.77) | LTA4HLAP3ANPEPRNPEPDNPEP | |
| SCHEMBL7964846 | 0.84 | LTA4H (0.77) | LTA4HLAP3ANPEPRNPEPDNPEP | |
| SCHEMBL2606756 | 0.84 | LTA4H (0.77) | LTA4HLAP3ANPEPRNPEPDNPEP | |
| SCHEMBL28578878 | 0.84 | LTA4H (0.77) | LTA4HLAP3ANPEPRNPEPDNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |