Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.69 |
| ▸ | LDHA | P00338 | 1/20 | 0.54 |
| ▸ | LAP3 | P28838 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960649 | 0.86 | LTA4H (0.67) | LTA4HLAP3 | |
| SCHEMBL7871920 | 0.86 | LDHA (0.65) | LTA4HLDHALAP3SLC6A4CYP1A2 | |
| SCHEMBL7415465 | 0.86 | LTA4H (0.67) | LTA4HLAP3 | |
| SCHEMBL20027598 | 0.86 | LDHA (0.56) | LTA4HLDHALAP3SLC6A4CYP1A2 | |
| SCHEMBL7426450 | 0.86 | LDHA (0.65) | LTA4HLDHALAP3SLC6A4CYP1A2 | |
| SCHEMBL741542 | 0.84 | LTA4H (0.61) | LTA4HLAP3POLBACACB | |
| SCHEMBL762691 | 0.84 | LTA4H (0.61) | LTA4HLAP3POLBACACB | |
| SCHEMBL741541 | 0.84 | LTA4H (0.61) | LTA4HLAP3POLBACACB | |
| SCHEMBL2606756 | 0.84 | LTA4H (0.77) | LTA4HLAP3CYP2C19 | |
| SCHEMBL6339522 | 0.84 | LTA4H (0.77) | LTA4HLAP3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271238-B1 | USEFUL IN TREATING AND PREVENTING DISEASES INVOLVING CHYMOTRYPSIN TYPE PROTEASES WHICH ARE RELATED TO ASTHMA, ALLERGY, INFLAMMATIONS, RHEUMATISM, HYPERTENSION, HEART FAILURE, MYOCARDIAL INFARCTION, AND CARDIAC HYPERTROPHY | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-08-07 | — | — | US | disclosed |
| EP-0936216-A1 | NOVEL ACETAMIDE DERIVATIVES AND PROTEASE INHIBITORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1999-08-18 | — | — | EP | disclosed |