Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.53 |
| ▸ | RXRB | P28702 | 1/20 | 0.53 |
| ▸ | RXRG | P48443 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1928824 | 0.93 | PLAAT3 (0.51) | TSHRFFAR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL18657080 | 0.88 | CYP4Z1 (0.49) | TSHRPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL764952 | 0.88 | SMN1; SMN2 (0.67) | TSHRHSD17B10HDAC3MAPK1ADRA1A | |
| SCHEMBL18373121 | 0.87 | HPGD (0.50) | TSHRHDAC8PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL16672973 | 0.87 | HPGD (0.50) | TSHRHDAC8PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL25172929 | 0.86 | HSD17B10 (0.65) | TSHRHSD17B10HDAC3MAPK1ADRA1A | |
| SCHEMBL22921868 | 0.86 | TSHR (0.58) | TSHRHSD17B10CYP4Z1CYP4F11CYP4F12 | |
| SCHEMBL31742285 | 0.84 | TSHR (0.53) | TSHRHSD17B10HDAC3MAPK1ADRA1A | |
| SCHEMBL24837831 | 0.83 | ALDH1A1 (0.61) | TSHRHSD17B10HDAC3MAPK1ADRA1A | |
| SCHEMBL11480209 | 0.83 | CYP4F2 (0.64) | TSHRHSD17B10HDAC3MAPK1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002022113-A2 | RETINOIC ACID RECEPTOR ANTAGONISTS AS PROMOTERS OF ANGIOGENESIS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-21 | — | — | WO | disclosed |
| EP-1173061-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES | Bristol-Myers Squibb Company (US) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000064260-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-11-02 | — | — | WO | disclosed |