Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.37 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416410 | 0.85 | KMO (0.46) | KMOCYP3A4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL30852338 | 0.78 | KMO (0.51) | KMOKDM4EHIF1ATDP1GRIK1 | |
| SCHEMBL30852376 | 0.78 | KMO (0.51) | KMOKDM4EHIF1ATDP1GRIK1 | |
| SCHEMBL31520067 | 0.78 | KMO (0.51) | KMOKDM4EHIF1ATDP1GRIK1 | |
| SCHEMBL1305231 | 0.78 | KMO (0.51) | KMOKDM4EHIF1ATDP1GRIK1 | |
| Av-101 SCHEMBL18742668 | 0.75 | KMO (0.51) | KMOCYP3A4SLC1A3SLC1A2SLC1A1 | |
| Av-101 SCHEMBL5286788 | 0.75 | KMO (0.51) | KMOCYP3A4SLC1A3SLC1A2SLC1A1 | |
| Av-101 SCHEMBL727370 | 0.75 | KMO (0.51) | KMOCYP3A4SLC1A3SLC1A2SLC1A1 | |
| Av-101 SCHEMBL30216614 | 0.75 | KMO (0.51) | KMOCYP3A4SLC1A3SLC1A2SLC1A1 | |
| Av-101 SCHEMBL30733184 | 0.75 | KMO (0.51) | KMOCYP3A4SLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756533-A | ENZYME INHIBITORS FOR TREATMENT OF AIDS | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5547991-A | NMDA antagonism method | MERRELL PHARMACEUTICALS INC. (US) | 1996-08-20 | — | — | US | disclosed |
| US-5484814-A | NMDA antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-01-16 | — | — | US | disclosed |
| US-5470870-A | New class of excitatory amino acid antagonist for epilepsy, anxiety or stroke | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0501378-B1 | NMDA Antagonists | MERRELL DOW PHARMA (US) | 1995-01-11 | — | — | EP | disclosed |
| US-5360814-A | NMDA antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-11-01 | — | — | US | disclosed |
| EP-0501378-A1 | NMDA Antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-02 | — | — | EP | disclosed |