Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | P4HB | P07237 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415685 | 1.00 | FBP1 (0.52) | FBP1FGFR1HTTMGAMGAA | |
| SCHEMBL29512158 | 0.76 | FGFR1 (0.72) | FGFR1HTTMGAMGAASI | |
| SCHEMBL2568999 | 0.76 | FGFR1 (0.72) | FGFR1HTTMGAMGAASI | |
| SCHEMBL3834819 | 0.76 | FGFR1 (0.72) | FGFR1HTTALDH1A1 | |
| SCHEMBL8388880 | 0.75 | HTT (0.70) | FGFR1HTTMGAMGAASI | |
| SCHEMBL30402227 | 0.74 | HTT (0.88) | FGFR1HTTALDH1A1 | |
| SCHEMBL3419279 | 0.74 | HTT (0.88) | FGFR1HTTALDH1A1 | |
| SCHEMBL7404429 | 0.73 | PDE3B (0.47) | FBP1ALDH1A1 | |
| SCHEMBL7404431 | 0.73 | PDE3B (0.47) | FBP1ALDH1A1 | |
| SCHEMBL10758359 | 0.73 | ALDH1A1 (0.58) | FBP1MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0102227-B1 | 2(1H)-PYRIDINONES, USEFUL AS CARDIOTONIC AGENTS, AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1989-05-03 | — | — | EP | disclosed |
| US-4607037-A | Cardiotonic 2(1H)-pyridinones | WARNER-LAMBERT COMPANY (US) | 1986-08-19 | — | — | US | disclosed |
| US-4503061-A | Substituted phenyl-pyridinones as cardiotonic agents | WARNER-LAMBERT COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0102227-A2 | 2(1H)-pyridinones, useful as cardiotonic agents, and their production | WARNER-LAMBERT COMPANY (US) | 1984-03-07 | — | — | EP | disclosed |