Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.47 |
| ▸ | PDE2A | O00408 | 2/20 | 0.44 |
| ▸ | FBP1 | P09467 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404429 | 1.00 | PDE3B (0.47) | PDE3BPDE3APDE2AFBP1ALDH1A1 | |
| SCHEMBL7293060 | 0.78 | PDE3B (0.54) | PDE3BPDE3APDE2AALDH1A1PDE1A | |
| SCHEMBL7415688 | 0.73 | FBP1 (0.52) | FBP1ALDH1A1 | |
| SCHEMBL7415685 | 0.73 | FBP1 (0.52) | FBP1ALDH1A1 | |
| SCHEMBL10758359 | 0.71 | ALDH1A1 (0.58) | PDE3BPDE3AFBP1ALDH1A1LMNA | |
| SCHEMBL10914452 | 0.71 | ALDH1A1 (0.58) | PDE3BPDE3AFBP1ALDH1A1LMNA | |
| SCHEMBL11204349 | 0.71 | FBP1 (0.56) | FBP1ALDH1A1LMNAMAPTMEN1 | |
| SCHEMBL11204347 | 0.71 | FBP1 (0.56) | FBP1ALDH1A1LMNAMAPTMEN1 | |
| SCHEMBL11006142 | 0.70 | PDE3B (0.52) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL11202335 | 0.69 | MITF (0.58) | FBP1ALDH1A1LMNAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0102227-B1 | 2(1H)-PYRIDINONES, USEFUL AS CARDIOTONIC AGENTS, AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1989-05-03 | — | — | EP | disclosed |
| US-4607037-A | Cardiotonic 2(1H)-pyridinones | WARNER-LAMBERT COMPANY (US) | 1986-08-19 | — | — | US | disclosed |
| US-4503061-A | Substituted phenyl-pyridinones as cardiotonic agents | WARNER-LAMBERT COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0102227-A2 | 2(1H)-pyridinones, useful as cardiotonic agents, and their production | WARNER-LAMBERT COMPANY (US) | 1984-03-07 | — | — | EP | disclosed |