Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | FPR2 | P25090 | 6/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | FPR1 | P21462 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27543459 | 0.88 | FPR2 (0.50) | FPR2FPR1KMT2AMEN1MMP9 | |
| SCHEMBL7416181 | 0.86 | FPR2 (0.62) | FPR2MMP9MMP8 | |
| SCHEMBL6374207 | 0.78 | FPR2 (0.62) | FPR2NAMPTFPR1KMT2AMEN1 | |
| SCHEMBL6374196 | 0.78 | FPR2 (0.62) | FPR2NAMPTFPR1KMT2AMEN1 | |
| SCHEMBL201265 | 0.76 | ECE1 (0.55) | NPC1RAB9AKMT2AMEN1MMP9 | |
| SCHEMBL27518028 | 0.76 | ECE1 (0.55) | NPC1RAB9AKMT2AMEN1MMP9 | |
| SCHEMBL10290541 | 0.75 | NAMPT (0.84) | NAMPTKMT2AMEN1POLB | |
| SCHEMBL14906475 | 0.75 | NAMPT (0.46) | NPC1RAB9AFPR2NAMPTFPR1 | |
| SCHEMBL7463584 | 0.75 | ANPEP (0.54) | NPC1FPR2POLB | |
| SCHEMBL202770 | 0.75 | CTSL (0.60) | KMT2AMMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218389-B1 | FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES | THE PROCTER & GAMBLE CO. | 2001-04-17 | — | — | US | disclosed |
| EP-1009737-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999006340-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |