Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.33 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.33 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | USP5 | P45974 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18782845 | 0.76 | — | — | |
| SCHEMBL23704476 | 0.66 | BAZ2B (0.46) | — | |
| SCHEMBL18906083 | 0.61 | CTNNB1 (0.68) | TSHRNR4A2ALDH1A1CYP2C19GAA | |
| Succinic Acid SCHEMBL156758 | 0.61 | — | — | |
| SCHEMBL18906052 | 0.60 | HCAR2 (0.54) | TSHRNR4A2ALDH1A1CYP2C19GAA | |
| SCHEMBL31584941 | 0.58 | ALDH1A1 (0.61) | TSHRNR4A2ALDH1A1CYP2C19GAA | |
| Succinic Acid SCHEMBL63117 | 0.58 | LMNA (0.82) | TSHRNR4A2KMT2ALMNAEGLN1 | |
| Succinic Acid SCHEMBL27241854 | 0.58 | LMNA (0.82) | TSHRNR4A2KMT2ALMNAEGLN1 | |
| Succinic Acid SCHEMBL2353391 | 0.58 | LMNA (0.82) | TSHRNR4A2KMT2ALMNAEGLN1 | |
| Succinic Acid SCHEMBL1475017 | 0.58 | LMNA (0.82) | TSHRNR4A2KMT2ALMNAEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4906630-A | Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds | RORER PHARMACEUTICAL CORPORATION (US) | 1990-03-06 | — | — | US | disclosed |
| US-4868300-A | INOTROPIC AGENTS, CONGESTIVE HEART FAILURE | RORER PHARMACEUTICAL CORPORATION (US) | 1989-09-19 | — | — | US | disclosed |
| US-4785101-A | CONGESTIVE HEART FAILURE | RORER PHARMACEUTICAL CORPORATION (US) | 1988-11-15 | — | — | US | disclosed |
| EP-0247177-A4 | BENZODIAZINONE-PYRIDAZINONE AND HYDROXY-PYRAZOLYL COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES. | RORER INTERNAT OVERSEAS INC (US) | 1988-04-06 | — | — | EP | disclosed |
| US-4725686-A | CONGESTIVE HEART FAILURE | WILLIAM H. RORER, INC. (US) | 1988-02-16 | — | — | US | disclosed |
| EP-0247177-A1 | BENZODIAZINONE-PYRIDAZINONE AND HYDROXY-PYRAZOLYL COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES | RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) (US) | 1987-12-02 | — | — | EP | disclosed |
| WO-1987003201-A1 | BENZODIAZINONE-PYRIDAZINONE AND HYDROXY-PYRAZOLYL COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1987-06-04 | — | — | WO | disclosed |