Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | YEATS4 | O95619 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4923028 | 0.82 | ALDH1A1 (0.50) | ALDH1A1PKMLRRK2LMNANPSR1 | |
| Hydrochloric Acid SCHEMBL4930234 | 0.81 | ALDH1A1 (0.49) | ALDH1A1PKMLRRK2LMNANPSR1 | |
| SCHEMBL4928078 | 0.81 | ALDH1A1 (0.49) | ALDH1A1PKMLRRK2LMNANPSR1 | |
| SCHEMBL7416513 | 0.79 | NPSR1 (0.60) | ALDH1A1LRRK2LMNANPSR1 | |
| SCHEMBL7414060 | 0.78 | NPSR1 (0.59) | ALDH1A1LRRK2LMNANPSR1TSHR | |
| SCHEMBL7433903 | 0.77 | ALDH1A1 (0.73) | ALDH1A1PKMLRRK2LMNANPSR1 | |
| SCHEMBL7437499 | 0.76 | HPGD (0.41) | ALDH1A1PKMLMNANPSR1HSD17B10 | |
| SCHEMBL7412721 | 0.76 | GABRA1 (0.47) | LRRK2LMNANPSR1HPGD | |
| SCHEMBL7418400 | 0.76 | LMNA (0.51) | ALDH1A1LRRK2LMNANPSR1HSD17B10 | |
| SCHEMBL7448893 | 0.74 | GABRA1 (0.48) | LRRK2LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156787-A | Substituted thienlycyclohexanone derivatives for enhancing cognition | MERCK SHARP & DOHME LIMITED (GB) | 2000-12-05 | — | — | US | disclosed |
| US-6143773-A | Substituted thienobenzisoxazole derivatives for enhancing cognition | MERCK SHARP & DOHME LIMITED (GB) | 2000-11-07 | — | — | US | disclosed |