Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 17/20 | 0.58 |
| ▸ | MMP9 | P14780 | 11/20 | 0.58 |
| ▸ | MMP13 | P45452 | 9/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 8/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414772 | 0.86 | ADAM17 (0.57) | ADAM17MMP9MMP13RAB9AMMP1 | |
| SCHEMBL7413633 | 0.85 | ADAM17 (0.56) | ADAM17MMP9MMP13MMP1HDAC3 | |
| SCHEMBL7414426 | 0.84 | ADAM17 (0.58) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL3939996 | 0.83 | ADAM17 (0.63) | ADAM17MMP9MMP13MMP1HDAC1 | |
| SCHEMBL7466803 | 0.81 | ADAM17 (0.59) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL3940241 | 0.81 | ADAM17 (0.73) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL3941406 | 0.81 | ADAM17 (0.56) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL4202703 | 0.80 | ADAM17 (0.55) | ADAM17MMP9MMP13MMP1HDAC1 | |
| SCHEMBL3945185 | 0.80 | ADAM17 (0.59) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL7418210 | 0.78 | ADAM17 (0.57) | ADAM17MMP9MMP13MMP1ADAM10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000044713-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | claimed |
| EP-1147080-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044713-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |