Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 12/20 | 0.57 |
| ▸ | MMP9 | P14780 | 6/20 | 0.57 |
| ▸ | MMP13 | P45452 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 3/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413633 | 0.87 | ADAM17 (0.56) | ADAM17MMP9MMP13MMP1HDAC1 | |
| SCHEMBL7415917 | 0.86 | ADAM17 (0.58) | ADAM17MMP9MMP13MMP1HDAC1 | |
| SCHEMBL7413415 | 0.84 | MAPT (0.39) | ADAM17MMP9MMP13MAPTL3MBTL1 | |
| SCHEMBL3939996 | 0.82 | ADAM17 (0.63) | ADAM17MMP9MMP13ALDH1A1MMP1 | |
| SCHEMBL7466803 | 0.81 | ADAM17 (0.59) | ADAM17MMP9MMP13MMP1 | |
| SCHEMBL3940241 | 0.80 | ADAM17 (0.73) | ADAM17MMP9MMP13MMP1 | |
| SCHEMBL3941406 | 0.80 | ADAM17 (0.56) | ADAM17MMP9MMP13MMP1 | |
| SCHEMBL3945185 | 0.79 | ADAM17 (0.59) | ADAM17MMP9MMP13MMP1 | |
| SCHEMBL6789274 | 0.78 | MAPT (0.44) | ADAM17MMP9MMP13MAPTL3MBTL1 | |
| SCHEMBL7418210 | 0.78 | ADAM17 (0.57) | ADAM17MMP9MMP13MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000044713-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | claimed |
| EP-1147080-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044713-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |