Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.71 |
| ▸ | CARM1 | Q86X55 | 11/20 | 0.59 |
| ▸ | PRMT1 | Q99873 | 11/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 3/20 | 0.57 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 2/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13706633 | 0.87 | CHRM2 (0.82) | CHRM2TAAR1MAOBBCHEACHE | |
| SCHEMBL27909715 | 0.84 | TAAR1 (0.59) | CHRM2TAAR1MAOBAOC3BCHE | |
| SCHEMBL19101439 | 0.84 | CHRM2 (0.73) | CHRM2MAOBAOC3BCHEACHE | |
| SCHEMBL8705108 | 0.83 | CHRM2 (0.71) | CHRM2MAOBAOC3BCHEACHE | |
| SCHEMBL4514454 | 0.80 | CHRM2 (0.67) | CHRM2TAAR1MAOBAOC3BCHE | |
| SCHEMBL1133192 | 0.80 | ACHE (0.55) | CHRM2TAAR1MAOBAOC3BCHE | |
| SCHEMBL4367373 | 0.80 | ACHE (0.65) | TAAR1MAOBBCHEACHE | |
| SCHEMBL19080598 | 0.78 | CHRM2 (0.72) | CHRM2CARM1PRMT1MAOBBCHE | |
| SCHEMBL735118 | 0.77 | SLC6A4 (0.68) | CHRM2TAAR1AOC3CHRM1 | |
| SCHEMBL11455232 | 0.77 | CARM1 (0.58) | CHRM2CARM1PRMT1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610165-A | N-acylpiperidine tachykinin antagonists | MERCK & CO., INC. (US) | 1997-03-11 | — | — | US | disclosed |
| WO-1995022525-A1 | N-ACYLPIPERIDINE TACHYKININ ANTAGONISTS | MERCK & CO., INC. (US) | 1995-08-24 | — | — | WO | disclosed |
| US-5344830-A | Anitinflammatory, cardiovascular, analgesic, central nervous system | MERCK & CO., INC. (US) | 1994-09-06 | — | — | US | disclosed |
| WO-1994013646-A1 | N,N-DIACYLPIPERAZINE TACHYKININ ANTAGONISTS | MERCK & CO., INC. (US) | 1994-06-23 | — | — | WO | disclosed |