Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 14/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 14/20 | 0.54 |
| ▸ | KDM4A | O75164 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7418353 | 0.96 | ITGB3 (0.51) | ITGB3ITGA2BKDM4APPARGITGAV | |
| SCHEMBL7418356 | 0.88 | ITGB3 (0.41) | ITGB3ITGA2BKDM4APPARG | |
| SCHEMBL7698475 | 0.87 | ITGB3 (0.50) | ITGB3ITGA2BKDM4APPARGMMP2 | |
| Trifluoroacetic Acid SCHEMBL7415034 | 0.84 | ITGB3 (0.47) | ITGB3ITGA2BKDM4APPARGPPARA | |
| SCHEMBL7412949 | 0.81 | ITGB3 (0.55) | ITGB3ITGA2BPPARGMMP2MMP9 | |
| SCHEMBL7409585 | 0.80 | ITGB3 (0.61) | ITGB3ITGA2BITGAVMMP2MMP9 | |
| SCHEMBL7411794 | 0.80 | POLB (0.48) | ITGB3ITGA2BMMP2MMP9KCNA5 | |
| SCHEMBL7695355 | 0.80 | BCL2 (0.49) | ITGB3ITGA2B | |
| SCHEMBL7409554 | 0.80 | MMP2 (0.61) | ITGB3ITGA2BMMP2MMP9 | |
| SCHEMBL7463648 | 0.80 | MAPT (0.46) | ITGB3ITGA2BKDM4AMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | claimed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | claimed |