Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 10/20 | 0.69 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.69 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.61 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.61 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.52 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.51 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416257 | 1.00 | CHRNB2 (0.69) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL7411564 | 0.83 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL7411561 | 0.83 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| Tebanicline SCHEMBL120178 | 0.76 | CHRNA3 (1.00) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| Tebanicline SCHEMBL120179 | 0.76 | CHRNA3 (1.00) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| Tebanicline SCHEMBL29711092 | 0.76 | CHRNA3 (1.00) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| Tebanicline SCHEMBL677444 | 0.76 | CHRNA3 (1.00) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| Tebanicline SCHEMBL15663031 | 0.75 | CHRNA3 (0.97) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| Tebanicline SCHEMBL7407195 | 0.75 | CHRNA3 (0.97) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| Tebanicline SCHEMBL15663029 | 0.75 | CHRNA3 (0.97) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | claimed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | claimed |
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |