SCHEMBL7416445

SCHEMBL7416445

CC1=C(C(=O)O)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2(C)CCCO2)=C(C)N1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1F O60840 10/20 0.58
CACNA1D Q01668 10/20 0.58
CACNA1S Q13698 10/20 0.58
CACNA1C Q13936 10/20 0.58
ADORA3 P0DMS8 1/20 0.58
CACNA1B Q00975 1/20 0.57
PDE1C Q14123 1/20 0.56
MEN1 O00255 4/20 0.55
CYP1A2 P05177 4/20 0.55
CYP3A4 P08684 4/20 0.55
CYP2C9 P11712 4/20 0.55
CYP2C19 P33261 4/20 0.55
KMT2A Q03164 4/20 0.55
HIF1A Q16665 3/20 0.55
MAPT P10636 3/20 0.55
LMNA P02545 3/20 0.55
CYP2D6 P10635 2/20 0.55
TSHR P16473 2/20 0.55
NFKB1 P19838 2/20 0.55
THPO P40225 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10671428 0.93 MEN1 (0.65) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL10364950 0.89 CACNA1B (0.54) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL10669458 0.87 CACNA1C (0.59) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL10668367 0.84 CACNA1C (0.49) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL10666488 0.82 CACNA1F (0.58) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL7424363 0.82 ADORA3 (0.58) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL3940339 0.82 CACNA1F (0.71) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL3032197 0.82 CACNA1F (0.71) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL7272138 0.81 MEN1 (0.76) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL7266605 0.81 MEN1 (0.76) CACNA1FCACNA1DCACNA1SCACNA1CADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0126094-A1 NEW 1,4-DIHYDROPYRIDINE ESTERS AND PREPARATION METHODS THEREOF AND DRUGS CONTAINING SAID ESTERS. CERMOL SA (CH) 1984-11-28 EP claimed
WO-1984002132-A1 NEW 1,4-DIHYDROPYRIDINE ESTERS AND PREPARATION METHODS THEREOF AND DRUGS CONTAINING SAID ESTERS CERMOL SA (CH) 1984-06-07 WO claimed
EP-0126094-B1 NEW 1,4-DIHYDROPYRIDINE ESTERS AND PREPARATION METHODS THEREOF AND DRUGS CONTAINING SAID ESTERS CERMOL S.A. (CH) 1990-06-20 EP disclosed
US-4727066-A CARDIOVASCULAR DISORDERS CERMOL S.A. (CH) 1988-02-23 US disclosed
US-4656181-A CARDIOTONIC AGENTS CERMOL S.A. (CH) 1987-04-07 US disclosed
EP-0126094-A1 NEW 1,4-DIHYDROPYRIDINE ESTERS AND PREPARATION METHODS THEREOF AND DRUGS CONTAINING SAID ESTERS. CERMOL SA (CH) 1984-11-28 EP disclosed
WO-1984002132-A1 NEW 1,4-DIHYDROPYRIDINE ESTERS AND PREPARATION METHODS THEREOF AND DRUGS CONTAINING SAID ESTERS CERMOL SA (CH) 1984-06-07 WO disclosed