SCHEMBL10668367

SCHEMBL10668367

CC1=C(C(=O)OC2CC(C)CC(C)(C)C2)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2(C)CCCO2)=C(C)N1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 4/20 0.49
CACNA1F O60840 3/20 0.49
CACNA1D Q01668 3/20 0.49
CACNA1S Q13698 3/20 0.49
ADORA3 P0DMS8 3/20 0.49
MEN1 O00255 5/20 0.47
KMT2A Q03164 5/20 0.47
CYP1A2 P05177 4/20 0.47
CYP3A4 P08684 4/20 0.47
CYP2C9 P11712 4/20 0.47
CYP2C19 P33261 4/20 0.47
HIF1A Q16665 3/20 0.47
MAPT P10636 3/20 0.47
LMNA P02545 3/20 0.47
CYP2D6 P10635 2/20 0.47
TSHR P16473 2/20 0.47
NFKB1 P19838 2/20 0.47
THPO P40225 2/20 0.47
POLB P06746 1/20 0.47
MAPK1 P28482 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10667044 0.85 HIF1A (0.64) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL10671428 0.84 MEN1 (0.65) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL7416445 0.84 CACNA1F (0.58) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL10665954 0.84 CACNA1F (0.72) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL10668372 0.81 POLB (0.55) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL10669458 0.79 CACNA1C (0.59) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL10666488 0.75 CACNA1F (0.58) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL10364950 0.74 CACNA1B (0.54) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL9765699 0.73 ABCB1 (0.71) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL9765742 0.73 ABCB1 (0.64) CACNA1CCACNA1FCACNA1DCACNA1SADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4656181-A CARDIOTONIC AGENTS CERMOL S.A. (CH) 1987-04-07 US claimed
US-4727066-A CARDIOVASCULAR DISORDERS CERMOL S.A. (CH) 1988-02-23 US disclosed
US-4656181-A CARDIOTONIC AGENTS CERMOL S.A. (CH) 1987-04-07 US disclosed