Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.42 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.33 |
| ▸ | HPRT1 | P00492 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4A | O75164 | 3/20 | 0.32 |
| ▸ | KDM4B | O94953 | 3/20 | 0.32 |
| ▸ | KDM5C | P41229 | 3/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21272824 | 0.76 | ADORA3 (0.51) | ADORA3HPRT1KDM4EGAAHPGD | |
| SCHEMBL364844 | 0.76 | ADORA3 (0.50) | ADORA3HPRT1KDM4EGAAHPGD | |
| SCHEMBL7062655 | 0.71 | ADORA3 (0.55) | ADORA3IP6K1KDM4EHPGDRAB9A | |
| SCHEMBL19208631 | 0.70 | ADORA3 (0.51) | ADORA3HPRT1KDM4EGAAHPGD | |
| Hydrochloric Acid SCHEMBL30194697 | 0.70 | ADORA3 (0.54) | ADORA3IP6K1KDM4EHPGDRAB9A | |
| SCHEMBL7419559 | 0.68 | ADORA3 (0.48) | ADORA3HPRT1KDM4EGAAHPGD | |
| SCHEMBL7422510 | 0.68 | ADORA3 (0.48) | ADORA3HPRT1KDM4EGAAHPGD | |
| SCHEMBL19208420 | 0.67 | KDM4E (0.44) | ADORA3HPRT1KDM4EGAAHPGD | |
| SCHEMBL7180282 | 0.65 | ADORA3 (0.52) | ADORA3IP6K1KDM4EHPGDRAB9A | |
| SCHEMBL4375637 | 0.65 | SRC (0.44) | IP6K1KDM4EPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220856-A2 | PYRAZOLO[4,3-D]PYRIMIDINE DERIVATIVES | Pfizer Limited (GB) | 2002-07-10 | — | — | EP | claimed |
| WO-2001027113-A2 | PYRAZOLO `4,3-d! PYRIMIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2001-04-19 | — | — | WO | claimed |