Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 8/20 | 0.71 |
| ▸ | RARG | P13631 | 8/20 | 0.71 |
| ▸ | RARA | P10276 | 6/20 | 0.71 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.52 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.52 |
| ▸ | RXRA | P19793 | 3/20 | 0.49 |
| ▸ | HNF4A | P41235 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9850154 | 0.86 | RARB (0.67) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL10563217 | 0.85 | RARB (0.70) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL10566002 | 0.84 | RARB (0.55) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL13479198 | 0.84 | RARB (0.58) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL10556841 | 0.83 | RARB (1.00) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL10556851 | 0.83 | RARB (1.00) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL26471804 | 0.83 | RARB (0.62) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL7422927 | 0.81 | RXRA (0.70) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL5712103 | 0.80 | RARB (0.80) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL8702828 | 0.79 | RARB (0.59) | RARBRARGRARACYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5837725-A | Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors | SRI INTERNATIONAL (US) | 1998-11-17 | — | — | US | disclosed |
| WO-1995033745-A9 | NOVEL COMPOUNDS USEFUL IN MODULATING GENE EXPRESSION OF RETINOID RESPONSIVE GENES AND/OR HAVING ANTI-AP-1 ACTIVITY | — | 1996-01-18 | — | — | WO | disclosed |
| WO-1995033745-A2 | NOVEL COMPOUNDS USEFUL IN MODULATING GENE EXPRESSION OF RETINOID RESPONSIVE GENES AND/OR HAVING ANTI-AP-1 ACTIVITY | SRI INTERNATIONAL (US) | 1995-12-14 | — | — | WO | disclosed |
| US-5466861-A | Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors | SRI INTERNATIONAL (US) | 1995-11-14 | — | — | US | disclosed |
| EP-0671005-A1 | RXR HOMODIMER FORMATION AND BRIDGED BICYCLIC AROMATIC COMPOUNDS AND THEIR USE IN MODULATING GENE EXPRESSION | LA JOLLA CANCER RESEARCH FOUNDATION (US) | 1995-09-13 | — | — | EP | disclosed |
| WO-1994012880-A2 | RXR HOMODIMER FORMATION AND BRIDGED BICYCLIC AROMATIC COMPOUNDS AND THEIR USE IN MODULATING GENE EXPRESSION | LA JOLLA CANCER RESEARCH FOUNDATION (US) | 1994-06-09 | — | — | WO | disclosed |
| US-4829080-A | SKIN DISORDERS, PSORIASIS, ACNE | L'OREAL (FR) | 1989-05-09 | — | — | US | disclosed |