Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.59 |
| ▸ | RARG | P13631 | 6/20 | 0.59 |
| ▸ | RARA | P10276 | 5/20 | 0.59 |
| ▸ | RXRA | P19793 | 6/20 | 0.55 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.48 |
| ▸ | CYP26B1 | Q9NR63 | 5/20 | 0.48 |
| ▸ | HNF4A | P41235 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8706853 | 0.88 | RXRA (0.71) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL8706133 | 0.84 | RXRA (0.76) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL8708590 | 0.81 | RARA (0.61) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL7417023 | 0.79 | RARB (0.71) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL8708782 | 0.79 | RXRA (0.74) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL9850154 | 0.77 | RARB (0.67) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL7454847 | 0.76 | RXRA (0.56) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL10556851 | 0.74 | RARB (1.00) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL10556841 | 0.74 | RARB (1.00) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL26471804 | 0.73 | RARB (0.62) | RARBRARGRARARXRACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5837725-A | Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors | SRI INTERNATIONAL (US) | 1998-11-17 | — | — | US | disclosed |
| WO-1995033745-A2 | NOVEL COMPOUNDS USEFUL IN MODULATING GENE EXPRESSION OF RETINOID RESPONSIVE GENES AND/OR HAVING ANTI-AP-1 ACTIVITY | SRI INTERNATIONAL (US) | 1995-12-14 | — | — | WO | disclosed |