Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.30 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.30 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380885 | 0.81 | HTR3E (0.38) | EPHX1IDO1 | |
| SCHEMBL7379832 | 0.77 | PRSS1 (0.42) | EPHX1IDO1SMN1; SMN2PARP10 | |
| SCHEMBL28323722 | 0.76 | IDO1 (0.42) | IDO1 | |
| SCHEMBL7377171 | 0.74 | HTT (0.46) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7386500 | 0.73 | IDO1 (0.42) | EPHX1IDO1 | |
| SCHEMBL5391144 | 0.73 | CA2 (0.46) | MEN1KMT2AEPHX1IDO1SMN1; SMN2 | |
| SCHEMBL27630839 | 0.72 | IDO1 (0.45) | EPHX1IDO1PKMSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5409279 | 0.71 | CA2 (0.45) | MEN1KMT2AEPHX1IDO1SMN1; SMN2 | |
| SCHEMBL5215999 | 0.71 | CA2 (0.55) | MEN1KMT2AIDO1 | |
| SCHEMBL7411026 | 0.70 | HDAC6 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165500-A1 | AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059874-A1 | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |