Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078097 | 0.80 | ALDH1A1 (0.37) | EPHX1L3MBTL1SMN1; SMN2CYP2C19MEN1 | |
| SCHEMBL7380886 | 0.77 | TPMT (0.34) | EPHX1CYP2C19 | |
| SCHEMBL7379834 | 0.77 | CYP2C19 (0.37) | EPHX1L3MBTL1CYP2C19 | |
| SCHEMBL7377175 | 0.74 | HTT (0.46) | L3MBTL1CYP2C19MEN1KMT2A | |
| SCHEMBL7386503 | 0.73 | CES2 (0.41) | EPHX1 | |
| SCHEMBL16962078 | 0.73 | — | — | |
| SCHEMBL16960988 | 0.72 | PARP1 (0.41) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7385340 | 0.69 | KDM4E (0.39) | L3MBTL1SMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL7562318 | 0.69 | PARP1 (0.46) | L3MBTL1CYP2C19 | |
| SCHEMBL16955142 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165500-A1 | AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059874-A1 | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |