Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.52 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.52 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.51 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.51 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199779 | 0.88 | ALDH1A1 (0.65) | LTA4HHRH3 | |
| SCHEMBL27002771 | 0.88 | MEN1 (0.56) | LTA4HMCHR1CHRNB2CHRNA4HRH3 | |
| SCHEMBL29495619 | 0.88 | ALDH1A1 (0.65) | LTA4HHRH3 | |
| SCHEMBL3662113 | 0.83 | CHRNA3 (0.51) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| Hydrochloric Acid SCHEMBL7674172 | 0.82 | CHRNA3 (0.50) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| Hydrochloric Acid SCHEMBL7663501 | 0.82 | CHRNA3 (0.50) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL17054992 | 0.81 | LTA4H (0.56) | LTA4HPTGS2MCHR1CHRNB2CHRNA4 | |
| SCHEMBL17054991 | 0.81 | LTA4H (0.56) | LTA4HPTGS2MCHR1CHRNB2CHRNA4 | |
| SCHEMBL7462908 | 0.80 | CHRNA3 (0.51) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL31372408 | 0.79 | MCHR1 (0.46) | LTA4HPTGS2MCHR1CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | claimed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | claimed |
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |