Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2219253 | 0.95 | CHRM2 (0.51) | CHRM2HPGDMAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL20837291 | 0.90 | NCF1 (0.44) | CHRM2HPGDMAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL2476416 | 0.81 | KDM4E (0.47) | CHRM2MAPTHSD17B10HTTHTR1A | |
| SCHEMBL20232562 | 0.78 | ALDH1A1 (0.42) | CHRM2HPGDMAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL2217667 | 0.77 | HTT (0.40) | CHRM2HPGDMAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL7745287 | 0.77 | PTGER4 (0.51) | CHRM2HPGDMAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL739875 | 0.77 | MAPT (0.58) | CHRM2HPGDMAPTSMN1; SMN2HTT | |
| Sulfuric Acid SCHEMBL7104162 | 0.75 | KDM4E (0.46) | CHRM2HSD17B10HTTHTR1AADRA1D | |
| SCHEMBL7771127 | 0.73 | CHRM2 (0.62) | CHRM2MAPTHSD17B10KDM4EGAA | |
| SCHEMBL1421223 | 0.73 | MAPT (0.54) | CHRM2HPGDMAPTHTTHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |