Sugi Predict

Sugi Predict / Compounds / Hydroxyamine

Hydroxyamine

Hydroxyamine

SCHEMBL7418152

COc1ccc(S(=O)(=O)N(Cc2ccccc2)c2c(C(=O)O)cnc3ccc(C(F)(F)F)cc23)cc1.NO

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ MMP13 P45452 17/20 0.82
▸ MMP1 P03956 16/20 0.82
▸ MMP9 P14780 15/20 0.82
▸ ADAM17 P78536 10/20 0.62
▸ TRPM8 Q7Z2W7 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6290541 0.98 MMP13 (0.85) MMP13MMP1MMP9ADAM17TRPM8
SCHEMBL7418158 0.92 MMP13 (0.80) MMP13MMP1MMP9ADAM17TRPM8
SCHEMBL6293309 0.92 MMP13 (0.85) MMP13MMP1MMP9ADAM17TRPM8
SCHEMBL7009343 0.90 MMP13 (1.00) MMP13MMP1MMP9ADAM17
SCHEMBL6290744 0.90 MMP13 (0.79) MMP13MMP1MMP9ADAM17
SCHEMBL6290010 0.86 MMP1 (0.85) MMP13MMP1MMP9ADAM17
SCHEMBL7349080 0.85 MMP9 (0.84) MMP13MMP1MMP9ADAM17
SCHEMBL7008346 0.84 MMP13 (0.78) MMP13MMP1MMP9ADAM17
SCHEMBL7012369 0.84 MMP13 (1.00) MMP13MMP1MMP9ADAM17
SCHEMBL6290574 0.83 MMP1 (0.67) MMP13MMP1MMP9ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1021413-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS American Cyanamid Company (US) 2000-07-26 — — EP disclosed
WO-1999018076-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1999-04-15 — — WO disclosed