Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | HPGD | P15428 | 7/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6093193 | 0.99 | KDM4E (0.59) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL6085357 | 0.80 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL1769987 | 0.77 | PTGES (0.57) | ALDH1A1HSD17B10TP53HTTMAPT | |
| SCHEMBL2445114 | 0.76 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL1770115 | 0.76 | ALDH1A1 (0.54) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL15219839 | 0.74 | KDM4E (0.75) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL6084644 | 0.71 | ALDH1A1 (0.52) | KDM4EALDH1A1P2RX7PTGESLMNA | |
| SCHEMBL6084262 | 0.70 | ALDH1A1 (0.54) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL1770138 | 0.68 | ALDH1A1 (0.56) | KDM4EALDH1A1MAPTTSHRP2RX7 | |
| SCHEMBL6083958 | 0.68 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDHSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037878-A2 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM DISEASES | NPS PHARMACEUTICALS, INC. (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999026927-A2 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM DISEASES | NPS PHARMACEUTICALS, INC. (US) | 1999-06-03 | — | — | WO | disclosed |