Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | STAT6 | P42226 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1770115 | 0.82 | ALDH1A1 (0.54) | PTGESALDH1A1HSD11B1LMNAKMT2A | |
| SCHEMBL6085750 | 0.79 | ALDH1A1 (0.58) | PTGESALDH1A1HSD11B1LMNAKMT2A | |
| SCHEMBL7418155 | 0.77 | KDM4E (0.60) | PTGESALDH1A1LMNAMAPTHTT | |
| SCHEMBL1770376 | 0.77 | HSD11B1 (0.54) | PTGESALDH1A1HSD11B1LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL6093193 | 0.76 | KDM4E (0.59) | PTGESALDH1A1LMNAMAPTHTT | |
| SCHEMBL1770138 | 0.75 | ALDH1A1 (0.56) | PTGESALDH1A1HSD11B1LMNASMN1; SMN2 | |
| SCHEMBL3320991 | 0.75 | ALDH1A1 (0.68) | ALDH1A1HSD11B1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL1770377 | 0.73 | PTGES (0.64) | PTGESALDH1A1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL1770030 | 0.73 | PTGES (0.52) | PTGESALDH1A1HSD11B1LMNAKMT2A | |
| SCHEMBL3323219 | 0.72 | HSD11B1 (0.52) | PTGESALDH1A1HSD11B1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112151-A1 | COMPOUND CAPABLE OF INHIBITING 11-BETA HYDROXYSTERIOD DEHYDROGENASE | STERIX LIMITED (GB) | 2011-05-12 | — | — | US | disclosed |
| EP-2257528-A2 | 1 IBETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Sterix Limited (GB) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009106817-A2 | COMPOUND | STERIX LIMITED (GB) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112151-A1 | COMPOUND CAPABLE OF INHIBITING 11-BETA HYDROXYSTERIOD DEHYDROGENASE | HSD11B1, HSD11B2, HSD3B1 | PTGES 814/4885ALDH1A1 307/4885HSD11B1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.