Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | MMP12 | P39900 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTPRA | P18433 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414375 | 1.00 | ELANE (0.49) | ELANEADAMTS4MMP8MMP12MMP13 | |
| SCHEMBL7332138 | 0.83 | ADAMTS4 (0.55) | ELANEADAMTS4MMP13MMP1MMP7 | |
| SCHEMBL7332133 | 0.83 | ADAMTS4 (0.55) | ELANEADAMTS4MMP13MMP1MMP7 | |
| SCHEMBL7423261 | 0.78 | ELANE (0.47) | ELANEMMP8MMP12MMP13MMP1 | |
| SCHEMBL7421516 | 0.78 | MBTPS1 (0.43) | ADAMTS4MMP13MMP1MMP7SMN1; SMN2 | |
| SCHEMBL7305790 | 0.72 | CA2 (0.55) | ADAMTS4SMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL6446955 | 0.71 | NPC1 (0.58) | SMN1; SMN2ALDH1A1KMT2ARAB9ACYP1A2 | |
| SCHEMBL6446960 | 0.71 | NPC1 (0.58) | SMN1; SMN2ALDH1A1KMT2ARAB9ACYP1A2 | |
| SCHEMBL7333019 | 0.71 | CA2 (0.64) | ELANEHTTATMSMN1; SMN2MEN1 | |
| SCHEMBL7332837 | 0.71 | CA2 (0.64) | ELANEHTTATMSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256677-A | Enzyme inhibitor for treating acquired immune deficiency syndrome | ABBOTT LABORATORIES (US) | 1993-10-26 | — | — | US | disclosed |
| WO-1992017176-A1 | RETROVIRAL PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-10-15 | — | — | WO | disclosed |
| US-5151438-A | Enzyme inhibitors for treatment of aids | ABBOTT LABORATORIES (US) | 1992-09-29 | — | — | US | disclosed |