Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | RGS12 | O14924 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15281193 | 0.87 | LMNA (0.45) | HPGDKMT2AMEN1TSHRLMNA | |
| SCHEMBL7421414 | 0.83 | KMT2A (0.57) | HPGDKMT2AMEN1TSHRLMNA | |
| SCHEMBL19787804 | 0.83 | HPGD (0.57) | HPGDKMT2AMEN1TSHRLMNA | |
| SCHEMBL8315368 | 0.80 | LMNA (0.50) | HPGDKMT2AMEN1TSHRLMNA | |
| SCHEMBL1272543 | 0.77 | ALDH1A1 (0.51) | HPGDKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL1272541 | 0.77 | ALDH1A1 (0.51) | HPGDKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL3759901 | 0.76 | LMNA (0.72) | HPGDKMT2AMEN1LMNASMN1; SMN2 | |
| Acetic Acid SCHEMBL28119023 | 0.76 | ALDH1A1 (0.57) | HPGDKMT2AMEN1TSHRLMNA | |
| SCHEMBL13173377 | 0.75 | HPGD (0.73) | HPGDKMT2AMEN1TSHRLMNA | |
| SCHEMBL2608954 | 0.75 | KMT2A (0.58) | HPGDKMT2AMEN1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861249-A1 | SUBSTITUTED SULFONYLALKANOYLAMINO HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-09-02 | — | — | EP | disclosed |
| US-5753660-A | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1997018205-A1 | SUBSTITUTED SULFONYLALKANOYLAMINO HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-05-22 | — | — | WO | disclosed |