Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9915159 | 0.88 | HDAC1 (0.42) | LMNAALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL10976954 | 0.80 | MTNR1A (0.63) | ALDH1A1MAPT | |
| SCHEMBL7418624 | 0.80 | HPGD (0.57) | LMNAALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL10976956 | 0.80 | MTNR1A (0.63) | ALDH1A1MAPT | |
| SCHEMBL10402318 | 0.80 | ALDH1A1 (0.50) | LMNAALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL24378375 | 0.79 | LMNA (0.48) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29092878 | 0.79 | LMNA (0.48) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL30616153 | 0.79 | LMNA (0.48) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10401984 | 0.78 | ALDH1A1 (0.49) | LMNAALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL25800370 | 0.77 | HDAC1 (0.42) | LMNAALDH1A1SMN1; SMN2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662481-B1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5578593-A | RELEASING GROWTH HORMONES FOR ANIMALS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0662481-A1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO. INC. (US) | 1995-07-12 | — | — | EP | disclosed |