Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18716950 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2HTR4ALDH1A1TSHRCNR1 | |
| SCHEMBL17963509 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2HTR4ALDH1A1TSHRCNR1 | |
| SCHEMBL26088109 | 0.85 | SMN1; SMN2 (0.55) | SMN1; SMN2HTR4ALDH1A1TSHRCNR1 | |
| SCHEMBL26088570 | 0.84 | SMN1; SMN2 (0.39) | SMN1; SMN2HTR4ALDH1A1TSHRCNR1 | |
| SCHEMBL7341765 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2HTR4ALDH1A1TSHRCNR1 | |
| SCHEMBL4130481 | 0.81 | HTR4 (0.46) | SMN1; SMN2HTR4ACHEHRH3KCNH2 | |
| SCHEMBL6986660 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1TSHRCNR1HRH3 | |
| SCHEMBL12813597 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2HTR4ALDH1A1TSHRCNR1 | |
| SCHEMBL12014400 | 0.79 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1TSHRTP53POLB | |
| SCHEMBL13510588 | 0.78 | SMN1; SMN2 (0.36) | SMN1; SMN2HTR4ALDH1A1TSHRCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173415-A1 | DIPHENYLUREA DERIVATIVES | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000064866-A1 | DIPHENYLUREA DERIVATIVES | ASTRAZENECA AB (SE) | 2000-11-02 | — | — | WO | disclosed |