Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 4/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17963509 | 0.91 | SMN1; SMN2 (0.44) | HTR4NR1H2HRH3ACHESMN1; SMN2 | |
| SCHEMBL25634866 | 0.84 | PAOX (0.42) | HTR4HTR1ADRD2SMN1; SMN2EPHX2 | |
| SCHEMBL18716950 | 0.82 | SMN1; SMN2 (0.44) | HTR4CHRM1CHRM2HTR1AADRA2A | |
| SCHEMBL18173283 | 0.81 | NR1H2 (0.43) | HTR4NR1H2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3885968 | 0.81 | HTR4 (0.41) | HTR4CHRM1CHRM2HTR1AADRA2A | |
| SCHEMBL7419075 | 0.81 | SMN1; SMN2 (0.43) | HTR4NR1H2CHRM1CHRM2HTR1A | |
| SCHEMBL21946902 | 0.80 | MEN1 (0.42) | HTR4CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL24269226 | 0.80 | HTR4 (0.40) | HTR4CHRM1CHRM2HTR1AADRA2A | |
| SCHEMBL25369363 | 0.80 | CYP1A2 (0.55) | HTR4HTR1AADRA2AHRH3ACHE | |
| SCHEMBL22181464 | 0.78 | NR1H2 (0.36) | NR1H2DRD2HRH3ACHEGNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090029958-A1 | PHENETHANOLAMINE DERIVATIVES AS BETA2 ADRENORECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029958-A1 | PHENETHANOLAMINE DERIVATIVES AS BETA2 ADRENORECEPTOR AGONISTS | ADRB2, ADRB1, ADRA2A | HTR4 146/4885NR1H2 158/4885CHRM1 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.