Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 6/20 | 0.44 |
| ▸ | FNTA | P49354 | 6/20 | 0.38 |
| ▸ | FNTB | P49356 | 6/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 5/20 | 0.38 |
| ▸ | FPR1 | P21462 | 3/20 | 0.38 |
| ▸ | USP14 | P54578 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412595 | 1.00 | ITGB3 (0.51) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7412598 | 1.00 | ITGB3 (0.51) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7419451 | 1.00 | ITGB3 (0.51) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7411896 | 0.87 | ITGB3 (0.47) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7417838 | 0.85 | ITGB3 (0.57) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7417832 | 0.85 | ITGB3 (0.57) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL8108543 | 0.84 | ITGB3 (0.71) | ITGB3ITGA2BFPR2FPR1 | |
| SCHEMBL8115160 | 0.84 | ITGB3 (0.71) | ITGB3ITGA2BFPR2FPR1 | |
| SCHEMBL7530926 | 0.84 | ITGB3 (0.51) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7415603 | 0.83 | ITGB3 (0.72) | ITGB3ITGA2BHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691953-B1 | 1-AMIDINOPHENYL-PYRROLIDONES/ PIPERIDINONES AS PLATELET AGGREGATION INHIBITORS | SEARLE & CO (US) | 2000-08-02 | — | — | EP | disclosed |
| WO-1994022820-A1 | 1-AMIDINOPHENYL-PYRROLIDONES PIPERIDINONES AZETINONES AS PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1994-10-13 | — | — | WO | disclosed |