Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
| ▸ | GRN | P28799 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7384272 | 0.86 | ALDH1A1 (0.40) | LTA4HRENMETAP2ALDH1A1KMT2A | |
| SCHEMBL4196009 | 0.83 | SLC1A3 (0.36) | LTA4HMETAP2SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4196007 | 0.83 | SLC1A3 (0.36) | LTA4HMETAP2SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL19690672 | 0.82 | SLC1A3 (0.43) | LTA4HSLC1A3SLC1A2SLC1A1GRN | |
| SCHEMBL28948924 | 0.79 | LTA4H (0.44) | LTA4HSLC1A3SLC1A2SLC1A1CPB2 | |
| SCHEMBL21197392 | 0.79 | LTA4H (0.44) | LTA4HSLC1A3SLC1A2SLC1A1CPB2 | |
| SCHEMBL5319747 | 0.79 | GRN (0.40) | LTA4HMETAP2SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL5319748 | 0.79 | GRN (0.40) | LTA4HMETAP2SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL2243927 | 0.79 | GRN (0.40) | LTA4HMETAP2SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL27237563 | 0.79 | SMN1; SMN2 (0.42) | LTA4HMETAP2ALDH1A1KMT2ASLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019386-A1 | REVERSE HYDROXAMATE DERIVATIVES AS METALLOPROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998038179-A1 | REVERSE HYDROXAMATE DERIVATIVES AS METALLOPROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 1998-09-03 | — | — | WO | disclosed |